La composition des larmes peut permettre de diagnostiquer certaines pathologies.
Les métabolites (molécules produites par l'organisme présentes dans les larmes), plus précisément dans le film lacrymal, peuvent servir de marqueurs pour diagnostiquer certaines pathologies (diabète, inflammations, maladies du foie, ...). C'est surtout dû à des échanges entre le sang et le film lacrymal.
La composition des larmes est donc changeante et reflète l'état de l'organisme. Mais cette publication n'aborde pas les causes de production des larmes.
La review est surtout dédiée aux lentilles de contact, la partie sur les larmes est une sorte d'introduction.
Contact lenses as a minimally invasive platform for diagnostics and drug delivery have emerged in recent years. Contact lens sensors have been developed for analyzing the glucose composition of tears as a surrogate for blood glucose monitoring and for the diagnosis of glaucoma by measuring intraocular pressure. However, the eye offers a wider diagnostic potential as a sensing site and therefore contact lens sensors have the potential to improve the diagnosis and treatment of many diseases and conditions. With advances in polymer synthesis, electronics and micro/nanofabrication, contact lens sensors can be produced to quantify the concentrations of many biomolecules in ocular fluids. Non- or minimally invasive contact lens sensors can be used directly in a clinical or point-of-care setting to monitor a disease state continuously. This article reviews the state-of-the-art in contact lens sensor fabrication, their detection, wireless powering, and readout mechanisms, and integration with mobile devices and smartphones. High-volume manufacturing considerations of contact lenses are also covered and a case study of an intraocular pressure contact lens sensor is provided as an example of a successful product. This Review further analyzes the contact lens market and the FDA regulatory requirements for commercialization of contact lens sensors.
