Negative social interactions may play an etiological role in both mental and physical illness, however the mechanisms underlying these effects are not well identified. The socially monogamous prairie vole (Microtus ochrogaster), which is reliant on its social context and forms social bonds similar to humans, has provided a useful model for investigating neurobiological systems that mediate sociality and reactivity to social stressors. In particular, the prairie vole is a powerful translational model for understanding the integration of behavioral and cardiac responses to acute and long-term stressors.