Article : RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
  • 1
  • Auteurs
    Dr AJ Wakefield, FRCS'Correspondence information about the author Dr AJ Wakefield, SH Murch, MB, A Anthony, MB, J Linnell, PhD, DM Casson, MRCP, M Malik, MRCP, M Berelowitz, FRCPsych, AP Dhillon, MRCPath, MA Thomson, FRCP, P Harvey, FRCP, A Valentine, FRCR, SE Davies, MRCPath, JA Walker-Smith, FRCP
  • Année de publication
    1998
  • Journal
    The Lancet
  • Abstract (dans sa langue originale)

    Background
    We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder.

    Methods
    12 children (mean age 6 years [range 3–10], 11 boys) were referred to a paediatric gastroenterology unit with a history of normal development followed by loss of acquired skills, including language, together with diarrhoea and abdominal pain. Children underwent gastroenterological, neurological, and developmental assessment and review of developmental records. Ileocolonoscopy and biopsy sampling, magnetic-resonance imaging (MRI), electroencephalography (EEG), and lumbar puncture were done under sedation. Barium follow-through radiography was done where possible. Biochemical, haematological, and immunological profiles were examined.

    Findings
    Onset of behavioural symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children, with measles infection in one child, and otitis media in another. All 12 children had intestinal abnormalities, ranging from lymphoid nodular hyperplasia to aphthoid ulceration. Histology showed patchy chronic inflammation in the colon in 11 children and reactive ileal lymphoid hyperplasia in seven, but no granulomas. Behavioural disorders included autism (nine), disintegrative psychosis (one), and possible postviral or vaccinal encephalitis (two). There were no focal neurological abnormalities and MRI and EEG tests were normal. Abnormal laboratory results were significantly raised urinary methylmalonic acid compared with agematched controls (p=0·003), low haemoglobin in four children, and a low serum IgA in four children.

    Interpretation
    We identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.

  • Identifiant unique
    http://dx.doi.org/10.1016/S0140-6736(97)11096-0
  • Accès libre
    Accéder à la référence
  • Apparait dans la controverse
    Quel est le bilan coût/bénéfice des vaccins à l'échelle des populations ?
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