Titre de l'article

Vin, alcool, plaquettes et le paradoxe français pour les maladies cardiaques coronariennes.

Ce que cet article apporte au débat

Il s'agit de l'un des premiers articles mettant en relation le paradoxe français (le fait que la France possède un taux de maladies cardiovasculaires nettement plus faible que ses autres voisins européens) et la consommation de vin.

Publiée il y a plus de 5 ans par N. Clairis.
Dernière modification il y a plus de 5 ans.
Article : Wine, alcohol, platelets, and the French paradox for coronary heart disease
  • Auteurs
    S. Renaud, M. de Lorgeril
  • Année de publication
    1992
  • Journal
    The Lancet
  • Abstract (dans sa langue originale)

    In most countries, high intake of saturated fat is positively related to high mortality from coronary heart disease (CHD). However, the situation in France is paradoxical in that there is high intake of saturated fat but low mortality from CHD. This paradox may be attributable in part to high wine consumption. Epidemiological studies indicate that consumption of alcohol at the level of intake in France (20-30 g per day) can reduce risk of CHD by at least 40%. Alcohol is believed to protect from CHD by preventing atherosclerosis through the action of high-density-lipoprotein cholesterol, but serum concentrations of this factor are no higher in France than in other countries. Re-examination of previous results suggests that, in the main, moderate alcohol intake does not prevent CHD through an effect on atherosclerosis, but rather through a haemostatic mechanism. Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD. Inhibition of platelet reactivity by wine (alcohol) may be one explanation for protection from CHD in France, since pilot studies have shown that platelet reactivity is lower in France than in Scotland.

  • Identifiant unique
    10.1016/0140-6736(92)91277-f
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  • Apparait dans la controverse
    Boire modérement et régulièrement du vin est-il bon pour la santé ?
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  • Boire modérement et régulièrement du vin est-il bon pour la santé ? Oui ou Non
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