Understanding how climate change and hunting influence population persistence is crucial for the conservation of animals such as ungulates that are economically important and also serve important ecological roles. Though the effects of hunting and climate change on wildlife demography and abundance have been studied in isolation, how these impacts interact is not well understood, particularly for tropical Asian ungulates, many of which are threatened with extinction. We used simulation modeling to assess how hunting and climate change could individually and jointly affect the persistence of three tropical Asian forest ungulates spanning a range of body sizes (muntjac, sambar deer, and Asian elephant). We found that the negative effects of climate change on these species could be reduced by altering the level of allowable harvest. Species with lower intrinsic growth rates (elephant and sambar) were vulnerable to even low levels of hunting but were less affected by climate change. We identified hunting thresholds beyond which further increases in harvest level greatly reduced persistence probabilities. Importantly, climate change can lower these thresholds and make species more vulnerable to overhunting, particularly those with relatively higher intrinsic growth rates such as muntjac. Much more information is needed on tropical Asian ungulate population ecology. In the meantime, however, our analysis suggests that wildlife managers focus on monitoring carrying capacity of ungulate populations and its variability over time, as this factor may be critical for assessing population responses to climatic changes, hunting, and their synergistic interactions.