Article : Lateralization and gender differences in the dopaminergic response to unpredictable reward in the human ventral striatum
  • Auteurs
    Chantal Martin-Soelch, Joanna Szczepanik, Allison Nugent, Krystle Barhaghi, Denise Rallis, Peter Herscovitch, Richard E. Carson, Wayne C. Drevets
  • Année de publication
  • Journal
    European Journal of Neuroscience
  • Abstract (dans sa langue originale)

    Electrophysiological studies have shown that mesostriatal dopamine (DA) neurons increase activity in response to unpredicted
    rewards. With respect to other functions of the mesostriatal dopaminergic system, dopamine’s actions show prominent laterality
    effects. Whether changes in DA transmission elicited by rewards also are lateralized, however, has not been investigated. Using
    [11C]raclopride-PET to assess the striatal DA response to unpredictable monetary rewards, we hypothesized that such rewards would
    induce an asymmetric reduction in [11C]raclopride binding in the ventral striatum, reflecting lateralization of endogenous dopamine
    release. In 24 healthy volunteers, differences in the regional D2 ⁄ 3 receptor binding potential (DBP) between an unpredictable reward
    condition and a sensorimotor control condition were measured using the bolus-plus-constant-infusion [11C]raclopride method. During
    the reward condition subjects randomly received monetary awards while performing a ‘slot-machine’ task. The DBP between
    conditions was assessed in striatal regions-of-interest and compared between left and right sides. We found a significant
    condition · lateralization interaction in the ventral striatum. A significant reduction in binding potential (BPND) in the reward condition
    vs. the control condition was found only in the right ventral striatum, and the DBP was greater in the right than the left ventral striatum.
    Unexpectedly, these laterality effects appeared to be partly accounted for by gender differences, as our data showed a significant
    bilateral BPND reduction in women while in men the reduction reached significance only in the right ventral striatum. These data
    suggest that DA release in response to unpredictable reward is lateralized in the human ventral striatum, particularly in males.

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