Review : The genetics of sex differences in brain and behavior
  • Auteurs
    Tuck C. Ngun, Negar Ghahramani, Francisco J. Sánchez, Sven Bocklandt, Eric Vilain
  • Année de publication
  • Journal
    Frontiers in Neuroendocrinology
  • Abstract (dans sa langue originale)

    Biological differences between men and women contribute to many sex-specific illnesses and disorders.
    Historically, it was argued that such differences were largely, if not exclusively, due to gonadal hormone
    secretions. However, emerging research has shown that some differences are mediated by mechanisms
    other than the action of these hormone secretions and in particular by products of genes located on
    the X and Y chromosomes, which we refer to as direct genetic effects. This paper reviews the evidence
    for direct genetic effects in behavioral and brain sex differences. We highlight the ‘four core genotypes’
    model and sex differences in the midbrain dopaminergic system, specifically focusing on the role of
    Sry. We also discuss novel research being done on unique populations including people attracted to
    the same sex and people with a cross-gender identity. As science continues to advance our understanding
    of biological sex differences, a new field is emerging that is aimed at better addressing the needs of both
    sexes: gender-based biology and medicine. Ultimately, the study of the biological basis for sex differences
    will improve healthcare for both men and women.

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    Y-a-t-il de réelles différences innées entre les cerveaux masculins et féminins ?
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  • Y-a-t-il de réelles différences innées entre les cerveaux masculins et féminins ? Oui ou Non